The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

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ABSTRACTThe protective effect of ethanolic propolis extract (PE) in the toxic effects of doxorubicin (DOX), a chemotherapy drug, has been reported previously.Since ethanol usage has some read more restrictions, in the present study, olive oil as an alternative to ethanol has been tested in DOX-induced hepatorenal injury and the effectiveness of the two extracts were compared.Male rats were orally given PE or oily propolis extract (PO) for 15 days (50 mg/kg/day) and DOX was injected (15 mg/kg, intraperitoneally) on the 13th day.The animals were sacrificed and then hepatorenal oxidative stress and functional parameters were evaluated.

DOX-induced reduction in hepatorenal functions and oxidative stress were significantly reduced in both propolis att nighthawk hotspot treatment groups.Treatment with PO was more effective in reducing DOX-induced oxidative stress, yet both extracts showed similar efficacy in improving hepatorenal functions.We suggest that the PO could be preferred to avoid the side effects of ethanol.